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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM343542
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Shepard, S; Shao, L; Wang, H Tricyclic heterocycles as bet protein inhibitors US Patent  US9777003 Publication Date 10/3/2017 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM343542
Synonyms:
US9777003, Example 141
Type:
Small organic molecule
Emp. Form.:
C18H15ClN6O
Mol. Mass.:
366.804
SMILES:
Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)C(=N)OC=N
Structure:
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