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Target
Retinol-binding protein 4
Ligand
BDBM249482
Substrate
n/a
Meas. Tech.
Scintillation Proximity Binding Assay
IC50
4.33±n/a nM
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US9777010 Publication Date 10/3/2017 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM249482
Synonyms:
US10072016, Compound 81 | US10407433, Compound 81 | US10913746, Compound 81 | US11649240, Compound 81 | US9434727, 80 | US9434727, 81 | US9777010, Compound 81
Type:
Small organic molecule
Emp. Form.:
C21H21F5N4O2
Mol. Mass.:
456.4091
SMILES:
CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Structure:
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