Reaction Details Report a problem with these data
Target
Retinol-binding protein 4
Ligand
BDBM249499
Substrate
n/a
Meas. Tech.
Scintillation Proximity Binding Assay
IC50
14.3±n/a nM
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US9777010 Publication Date 10/3/2017 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM249499
Synonyms:
US10072016, Compound 97 | US10407433, Compound 97 | US10913746, Compound 97 | US11649240, Compound 97 | US9434727, 97 | US9777010, Compound 97
Type:
Small organic molecule
Emp. Form.:
C22H23F5N4O
Mol. Mass.:
454.4362
SMILES:
Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CC4CC4)Cc23)c(c1F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: