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Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM345118
Substrate
n/a
Meas. Tech.
Kinase High ATP Assay
IC50
31.0±n/a nM
Citation
 Zorn, L; Eis, K; Schulze, V; Sülzle, D; Puehler, F; Lienau, P; Bömer, U; Petersen, K; Hägebarth, A Aminoimidazopyridazines US Patent  US9783543 Publication Date 10/10/2017 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM345118
Synonyms:
US9783543, 10 | trans-4-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexanol
Type:
Small organic molecule
Emp. Form.:
C20H20N4O2
Mol. Mass.:
348.3984
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r,wU:1.0,wD:4.7,(-7.09,4.57,;-5.76,3.8,;-4.42,4.57,;-3.09,3.8,;-3.09,2.26,;-4.42,1.49,;-5.76,2.26,;-1.76,1.49,;-.42,2.26,;-.42,3.8,;.91,4.57,;2.25,3.8,;3.71,4.28,;4.62,3.03,;3.71,1.79,;4.48,.45,;3.58,-.79,;4.48,-2.04,;4.16,-3.54,;5.3,-4.57,;6.77,-4.1,;7.09,-2.59,;5.95,-1.56,;5.95,-.02,;2.25,2.26,;.91,1.49,)|
Structure:
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