Reaction Details Report a problem with these data
Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM345311
Substrate
n/a
Meas. Tech.
Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells
IC50
133000±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM345311
Synonyms:
2-[[1-(2-chlorophenyl)-5-(3-methoxyphenyl)- 1H-pyrazol-3-yl]methoxy]-2- methylpropanoic acid LC-MS (ES, m/z): 401 1H-NMR (400 MHz, MeOD) $#948; 1.55 (6 H, s), 3.64 (3 H, s), 4.63 (2 H, s), 6.73 (2 H, d), 6.86 (2 H, dd), 7.20 (1 H, dd), 7.42-7.60 (4 H, m). | US10202350, Example 57 | US10214492, Example 57 | US11292767, Example 57 | US11724989, Example 57
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O4
Mol. Mass.:
400.855
SMILES:
COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: