Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349509
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
52.0±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US10207991 Publication Date 2/19/2019 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349509
Synonyms:
US10207991, Ex. Cpd. No. 24 | US10611728, Example Compound 24 | US11691947, Example 24
Type:
Small organic molecule
Emp. Form.:
C20H20F3NO4
Mol. Mass.:
395.3723
SMILES:
C[C@H](CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cc3OCOc3cc2C1 |r|
Structure:
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