Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM349546
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
33.0±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US10207991 Publication Date 2/19/2019 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM349546
Synonyms:
US10207991, Ex. Cpd. No. 61 | US10611728, Example Compound 61 | US11691947, Example 61
Type:
Small organic molecule
Emp. Form.:
C21H24F3NO4S
Mol. Mass.:
443.48
SMILES:
CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Structure:
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