Reaction Details Report a problem with these data
Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM205019
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.3±n/a
IC50
30.0±0 nM
Comments
extracted
Citation
 Demnitz, J; Jorgensen, S Tetrazole derivatives and their use as potassium channel modulators US Patent  US9556132 Publication Date 1/31/2017 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM205019
Synonyms:
US9556132, 4 | process for preparing 1-(2-fluorophenyl)-5-{2-[2-(2-methoxyethoxyl)phenyl]phenyl}-1h-1,2,3,4-tetrazole
Type:
Small organic molecule
Emp. Form.:
C22H19FN4O2
Mol. Mass.:
390.4103
SMILES:
COCCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: