Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
Ligand
BDBM14772
Substrate
BDBM10851
Meas. Tech.
Phosphodiesterase (PDE) Inhibition Assay
IC50
1100±n/a nM
Citation
 Card, GLEngland, BPSuzuki, YFong, DPowell, BLee, BLuu, CTabrizizad, MGillette, SIbrahim, PNArtis, DRBollag, GMilburn, MVKim, SHSchlessinger, JZhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure 12:2233-47 (2004) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
Synonyms:
DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase Type 4 (PDE4D) | cAMP-specific 3,5-cyclic phosphodiesterase 4D
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40034.37
Organism:
Homo sapiens (Human)
Description:
RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D.
Residue:
349
Sequence:
MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS
  
Inhibitor
Name:
BDBM14772
Synonyms:
(R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-methyl-1,3-oxazolidin-2-one | 5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one | Daxalipram
Type:
Small organic molecule
Emp. Form.:
C14H19NO4
Mol. Mass.:
265.305
SMILES:
CCCOc1cc(ccc1OC)C1(C)CNC(=O)O1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10851
Synonyms:
(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide | ADENOSINE-3 ,5 -CYCLIC-MONOPHOSPHATE | Cyclic adenosine monophosphate | cAMP | cid_23902375
Type:
Small organic molecule
Emp. Form.:
C10H12N5O6P
Mol. Mass.:
329.2059
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
Structure:
Search PDB for entries with ligand similarity: