Reaction Details Report a problem with these data
Target
Atypical chemokine receptor 3
Ligand
BDBM345988
Substrate
n/a
Meas. Tech.
In Vitro Assay
EC50
18.0±n/a nM
Citation
 Guerry, P; Lehembre, F; Pothier, J; Siendt, H CXCR7 receptor modulators US Patent  US10202368 Publication Date 2/12/2019 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM345988
Synonyms:
2-(4-cyclopropylmethyl-3-oxo-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-9-ylamino)-N-(2-pyrrolidin-1-yl-ethyl)-N-(3-trifluoromethyl-pyridin-2-ylmethyl)-acetamide | US10202368, Example 65
Type:
Small organic molecule
Emp. Form.:
C28H34F3N5O3
Mol. Mass.:
545.5965
SMILES:
FC(F)(F)c1cccnc1CN(CCN1CCCC1)C(=O)CNc1cccc2CN(CC3CC3)C(=O)COc12
Structure:
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