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Target
Protein Wnt-3a
Ligand
BDBM346239
Substrate
n/a
Meas. Tech.
Dual-Cell beta-Catenin Reporter Assay
IC50
<1±n/a nM
Citation
 Bhamra, I; Mathieson, M; Donoghue, C; Testar, R N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors US Patent  US10202375 Publication Date 2/12/2019 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM346239
Synonyms:
2-[5-fluoro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]pyridin-1-yl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide | US10202375, Example 2 | US10202375, Example 9
Type:
Small organic molecule
Emp. Form.:
C24H18FN7O
Mol. Mass.:
439.4444
SMILES:
Cc1cc(ccn1)-c1c(F)cnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Structure:
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