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Target
Protein Wnt-3a
Ligand
BDBM346243
Substrate
n/a
Meas. Tech.
Dual-Cell beta-Catenin Reporter Assay
IC50
>5±n/a nM
Citation
 Bhamra, I; Mathieson, M; Donoghue, C; Testar, R N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors US Patent  US10202375 Publication Date 2/12/2019 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM346243
Synonyms:
2-[4-(2-methylpyrazol-3-yl)pyrazolo[3,4-b]pyridin-1-yl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide | US10202375, Example 6
Type:
Small organic molecule
Emp. Form.:
C21H17N9O
Mol. Mass.:
411.4194
SMILES:
Cn1nccc1-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ncc12
Structure:
Search PDB for entries with ligand similarity: