Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM205086
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
30.8±0 nM
Citation
 Kuduk, SD; Skudlarek, JW 2-pyridyloxy-4-ester orexin receptor antagonists US Patent  US9556145 Publication Date 1/31/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM205086
Synonyms:
US9556145, example 6 | dimethyl 2-{[(3r,6r)-6-methyl-1- {[2-(2h-1,2,3-triazol-2-yl)phenyl]- carbonyl}-piperidin-3- yl]oxy}pyridine-3,4-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C24H25N5O6
Mol. Mass.:
479.4852
SMILES:
COC(=O)c1ccnc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)c1C(=O)OC
Structure:
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