Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM14879
Substrate
BDBM13777
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
88±n/a nM
Citation
 Riggs, JR; Hu, H; Kolesnikov, A; Leahy, EM; Wesson, KE; Shrader, WD; Vijaykumar, D; Wahl, TA; Tong, Z; Sprengeler, PA; Green, MJ; Yu, C; Katz, BA; Sanford, E; Nguyen, M; Cabuslay, R; Young, WB Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett 16:3197-200 (2006) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM14879
Synonyms:
3-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}phenyl)phenyl]methyl}-1-(4-methoxyphenyl)urea | 5-azaindole analog 17
Type:
Small organic molecule
Emp. Form.:
C28H24N4O3
Mol. Mass.:
464.5152
SMILES:
COc1ccc(NC(=O)NCc2cccc(c2)-c2cccc(-c3cc4cnccc4[nH]3)c2O)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM13777
Synonyms:
(2S)-5-carbamimidamido-2-{2-[(2R)-3-cyclohexyl-2-methanesulfonamidopropanamido]butanamido}-N-(4-nitrophenyl)pentanamide; acetic acid | CH3SO2-D-CHA-But-Arg-pNA. AcOH | Pefachrome FVIIa
Type:
Small organic molecule
Emp. Form.:
C26H42N8O7S
Mol. Mass.:
610.726
SMILES:
CCC(NC(=O)C(CC1CCCCC1)NS(C)(=O)=O)C(=O)NC(CCC\[NH+]=C(\N)[NH-])C(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: