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TargetUbiquitin carboxyl-terminal hydrolase isozyme L5
LigandBDBM65518
Substrate/Competitorn/a
Meas. Tech.Fluorometric Ub-AMC Hydrolysis Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 16200±n/a nM
Commentsextracted
Citation Ott, CABaljinnyam, BZakharov, AVJadhav, ASimeonov, AZhuang, Z Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol12:2399-2407 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Name:Ubiquitin carboxyl-terminal hydrolase isozyme L5
Synonyms:CGI-70 | UCH-L5 | UCH37 | UCHL5 | Ubiquitin C-terminal hydrolase UCH37 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Ubiquitin thioesterase L5
Type:PROTEIN
Mol. Mass.:37597.89
Organism:Homo sapiens (Human)
Description:ChEMBL_109575
Residue:329
Sequence:
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQP
GEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQS
FDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDG
LREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQR
QLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELL
KTLAEHQQLIPLVEKAKEKQNAKKAQETK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM65518
NameBDBM65518
Synonyms:5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) | 668467-91-2 | LDN-57444
TypeSmall organic molecule
Emp. Form.C17H11Cl3N2O3
Mol. Mass.397.64
SMILESCC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Cl)cc12 |w:4.3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a