Ki Summary

Reaction Details

Report a problem with these data

Target

Ubiquitin carboxyl-terminal hydrolase isozyme L5

Ligand

BDBM205457

Substrate/Competitor

n/a

Meas. Tech.

Fluorometric Ub-AMC Hydrolysis Assay

7.5±n/a

Temperature

298.15±n/a K

IC50

56600±n/a nM

Comments

extracted

Citation

Ott, CA; Baljinnyam, B; Zakharov, AV; Jadhav, A; Simeonov, A; Zhuang, Z Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol12:2399-2407 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Ubiquitin carboxyl-terminal hydrolase isozyme L5

Name:

Ubiquitin carboxyl-terminal hydrolase isozyme L5

Synonyms:

Type:

PROTEIN

Mol. Mass.:

37597.89

Organism:

Homo sapiens (Human)

Description:

ChEMBL_109575

Residue:

329

Sequence:

MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQP
GEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQS
FDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDG
LREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQR
QLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELL
KTLAEHQQLIPLVEKAKEKQNAKKAQETK

BDBM205457

Name

BDBM205457

Synonyms:

(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid | Celastrol

Type

Small organic molecule

Emp. Form.

C29H38O4

Mol. Mass.

450.6096

SMILES

CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |r,c:1,6,11,t:9|

Structure

n/a