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TargetUbiquitin-like modifier-activating enzyme 1
LigandBDBM329802
Substrate/Competitorn/a
Meas. Tech.Ubiquitin Activating Enzyme (UAE) HTRF Assay
IC50<10±n/a nM
Citation Afroze, RBharathan, ITCiavarri, JPFleming, PEGaulin, JLGirard, MLangston, SPSoucy, FWong, TYe, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US10202389 Publication Date 2/12/2019
More Info.:Get all data from this article,  Assay Method
 
Ubiquitin-like modifier-activating enzyme 1
Name:Ubiquitin-like modifier-activating enzyme 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:117834.03
Organism:Homo sapiens (Human)
Description:ChEMBL_827630
Residue:1058
Sequence:
MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY
VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE
EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH
NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH
GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK
ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA
LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI
MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG
CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN
PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT
LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA
ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN
NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG
SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP
GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA
VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV
QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS
RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
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  Blast E-value cutoff:
BDBM329802
NameBDBM329802
Synonyms:(rac)-((1R,2R,3S,4R)-4-(2-(dibenzo[b,d]furan-4-yl)pyrazolo[1,5-a]pyrimidin-7- | US10202389, Compound I-103 | US9663525, Compound I-010 | US9663525, Compound I-103 | US9796725, Compound I-010
TypeSmall organic molecule
Emp. Form.C24H23N5O6S
Mol. Mass.509.534
SMILESNS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc3c4ccccc4oc23)[C@H](O)[C@@H]1O |r|
Structure
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n/a