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Target
Ubiquitin-like modifier-activating enzyme 1
Ligand
BDBM329917
Substrate
n/a
Meas. Tech.
Ubiquitin Activating Enzyme (UAE) HTRF Assay
IC50
550±n/a nM
Citation
 Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US10202389 Publication Date 2/12/2019 
Target
Name:
Ubiquitin-like modifier-activating enzyme 1
Synonyms:
A1S9T | UBA1 | UBA1_HUMAN | UBE1
Type:
PROTEIN
Mol. Mass.:
117834.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_827630
Residue:
1058
Sequence:
MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
  
Inhibitor
Name:
BDBM329917
Synonyms:
(s.e.)-{(1R,2R,3S,4R)-4-[(6-chloro-2-{3-[(trifluoromethyl)sulfanyl]phenyl}pyrazolo[1, | US10202389, Compound I-125 | US9663525, Compound I-125 | US9796725, Compound I-125
Type:
Small organic molecule
Emp. Form.:
C19H19ClF3N5O5S2
Mol. Mass.:
553.963
SMILES:
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2c(Cl)cnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O |r|
Structure:
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