Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431086
Substrate
n/a
Meas. Tech.
DAAO Inhibitory Activity Assay
IC50
3.10±n/a nM
Citation
 Hondo, T; Nakanishi, K; Niimi, T; Warizaya, M; Namatame, I; Harada, K Dihydroxy aromatic heterocyclic compound US Patent  US10202399 Publication Date 2/12/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50431086
Synonyms:
CHEMBL2338800 | US10202399, Example 212 | US10463663, Example 2 | US11129828, Example 2 | US9212147, 212 | US9290456, 2 | US9931340, Example 2
Type:
Small organic molecule
Emp. Form.:
C12H11FN2O2
Mol. Mass.:
234.2263
SMILES:
Oc1cc(CCc2ccc(F)cc2)n[nH]c1=O
Structure:
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