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TargetcAMP-Dependent Protein Kinase (PKA)
LigandBDBM15067
Substrate/Competitorbiotinylated kemptide
Meas. Tech.PKA/PKC Kinase Assay
IC50 2.1±n/a nM
Citation Li, QWoods, KWThomas, SZhu, GDPackard, GFisher, JLi, TGong, JDinges, JSong, XAbrams, JLuo, YJohnson, EFShi, YLiu, XKlinghofer, VDes Jong, ROltersdorf, TStoll, VSJakob, CGRosenberg, SHGiranda, VL Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett16:2000-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cAMP-Dependent Protein Kinase (PKA)
Name:cAMP-dependent protein kinase A
Synonyms:PKA C-alpha | PKC | Protein Kinase C | Protein Kinase C, bovine brain | cAMP-dependent Protein Kinase, bovine heart | cAMP-dependent protein kinase A | cAMP-dependent protein kinase alpha-catalytic subunit | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:Enzyme Complex
Mol. Mass.:40627.77
Organism:Bos taurus (bovine)
Description:The PKA holoenzyme purified from bovine heart, exists as an inactive tetrameric complex, which consists of a regulatory dimer associated with two catalytic subunits. It requires cAMP to activate the enzymatic reaction.
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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  Blast E-value cutoff:
BDBM15067
NameBDBM15067
Synonyms:(2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine | 13a (S-) | 5-isoquinolinyl pyridine 2 | 6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinoline | isoquinoline-pyridine, 1 | isoquinoline-pyridine, 3 | pyridine-base inhibitor 13a
TypeSmall organic molecule
Emp. Form.C25H22N4O
Mol. Mass.394.4684
SMILESN[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
biotinylated kemptide
Name:biotinylated kemptide
Synonyms:n/a
Type:Biotinylated Peptide
Mol. Mass.:1353.09
Organism:n/a
Description:n/a
Residue:12
Sequence:
biotin-hx-LRRASLG