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Target
Protein M2-1
Ligand
BDBM347280
Substrate
n/a
Meas. Tech.
Cytopathic Effect Assay with RSV A2 in MA-104
EC50
>167000±n/a nM
Citation
 Sommadossi, J; Moussa, A β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections US Patent  US10202412 Publication Date 2/12/2019 
Target
Name:
Protein M2-1
Synonyms:
Envelope-associated 22 kDa protein | M2-1 | M21_HRSVA | Matrix M2-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22163.59
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
P04545
Residue:
194
Sequence:
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
  
Inhibitor
Name:
BDBM347280
Synonyms:
US10202412, Compound T
Type:
Small organic molecule
Emp. Form.:
C25H35FN7O7P
Mol. Mass.:
595.5603
SMILES:
CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@@]1(C)O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(nc(N)nc12)N(C)C)Oc1ccccc1 |r|
Structure:
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