Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM223016
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<750±n/a nM
Citation
 Combs, AP; Yue, EW; Sparks, RB; Zhu, W 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase US Patent  US9789094 Publication Date 10/17/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM223016
Synonyms:
US10034939, Example 18 | US10967060, Example 18 | US11207302, Example 18 | US9320732, 18 | US9789094, 18
Type:
Small organic molecule
Emp. Form.:
C12H13FN8O4S
Mol. Mass.:
384.346
SMILES:
NS(=O)(=O)NCCNc1nonc1C(Nc1ccc(F)c(c1)C#N)=NO |w:24.26|
Structure:
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