Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM348884
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
2.69±n/a nM
Citation
 Wright, DL; Anderson, AC; Van Heyst, M; Ononye, S Substituted tropolone derivatives and methods of use US Patent  US9790158 Publication Date 10/17/2017 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM348884
Synonyms:
US9790158, 10
Type:
n/a
Emp. Form.:
C11H14O2
Mol. Mass.:
178.2277
SMILES:
CC(C)(C)c1cccc(O)c(=O)c1
Structure:
Search PDB for entries with ligand similarity: