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Target
Histone deacetylase 3
Ligand
BDBM347481
Substrate
n/a
IC50
149±n/a nM
Citation
 van Duzer, JH; Mazitschek, R Piperidine derivatives as HDAC1/2 inhibitors US Patent  US9790180 Publication Date 10/17/2017 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM347481
Synonyms:
US9790180, ID 015
Type:
Small organic molecule
Emp. Form.:
C28H34N6O2S
Mol. Mass.:
518.674
SMILES:
CC1(CCN(CC1)C(=O)N1CCNCC1)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1
Structure:
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