Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDihydroorotate dehydrogenase
LigandBDBM15341
Substrate/CompetitorBDBM14700
Meas. Tech.DHODH Inhibition Assay
pH8±n/a
Temperature303.15±n/a K
IC50 2±n/a nM
Citation Baumgartner, RWalloschek, MKralik, MGotschlich, ATasler, SMies, JLeban, J Dual binding mode of a novel series of DHODH inhibitors. J Med Chem49:1239-47 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:DHOdehase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH)
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM15341
NameBDBM15341
Synonyms:3-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phenyl}carbamoyl)thiophene-2-carboxylic acid | Compound 7
TypeSmall organic molecule
Emp. Form.C19H10F5NO4S
Mol. Mass.443.344
SMILESOC(=O)c1sccc1C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM14700
NameBDBM14700
Synonyms:2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione | Decylubiquinone
TypeUbiquinone analog
Emp. Form.C19H30O4
Mol. Mass.322.4391
SMILESCCCCCCCCC=Cc1c(C)c(O)c(OC)c(OC)c1O |w:9.9|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: