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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
Ligand
BDBM15355
Substrate
BDBM15346
Meas. Tech.
DHODH Inhibition Assay
IC50
370±n/a nM
Citation
 Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 280:21847-53 (2005) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
Synonyms:
DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | pfR265A
Type:
Enzyme
Mol. Mass.:
65495.77
Organism:
Plasmodium falciparum
Description:
Q54A96[R265A]
Residue:
569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYYNKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNKKDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFADVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKHSKS
  
Inhibitor
Name:
BDBM15355
Synonyms:
2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide | Asinex compound no. 10
Type:
Small organic molecule
Emp. Form.:
C15H11F3N2O3
Mol. Mass.:
324.2546
SMILES:
Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
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Substrate
Name:
BDBM15346
Synonyms:
2,3-dimethoxy-5-methyl-cyclohexa-2,5-diene-1,4-dione | 2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione | Ubiquinone-0 (CoQ0)
Type:
Small organic molecule
Emp. Form.:
C9H10O4
Mol. Mass.:
182.1733
SMILES:
COC1=C(OC)C(=O)C(C)=CC1=O |c:2,9|
Structure:
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