Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300833
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
EC50
16.0±0 nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US9790198 Publication Date 10/17/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300833
Synonyms:
2-((1r,3r)-3-Hydroxy-1-(4-((3- (2-methylphenyl) benzo[b]thiophen-5- yl)methoxy)phenyl)cyclobutyl) acetic acid | US10131648, Compound 31 | US10195178, Compound 31 | US9790198, Compound 31
Type:
Small organic molecule
Emp. Form.:
C28H26O4S
Mol. Mass.:
458.569
SMILES:
Cc1ccccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12 |r,wU:22.23,wD:28.30,(-4.31,-.63,;-5.64,-1.4,;-5.64,-2.94,;-6.98,-3.71,;-8.31,-2.94,;-8.31,-1.4,;-6.98,-.63,;-6.98,.91,;-8.22,1.82,;-7.75,3.28,;-6.21,3.28,;-5.17,4.43,;-3.67,4.11,;-3.19,2.64,;-1.71,2.24,;-1.31,.76,;.18,.36,;.58,-1.13,;2.07,-1.53,;3.16,-.44,;2.76,1.05,;1.27,1.45,;4.64,-.84,;5.73,.25,;7.22,-.15,;8.31,.94,;7.62,-1.63,;5.98,-1.61,;5.21,-2.94,;5.61,-4.43,;3.87,-2.17,;-4.22,1.5,;-5.73,1.82,)|
Structure:
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