Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300868
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
EC50
14.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US9790198 Publication Date 10/17/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300868
Synonyms:
(3S)-3-[4-([3-[2-(2- Methoxyethoxy)-6- methylphenyl]-1- benzothiophen-5- yl]methoxy)phenyl] hex-4-ynoic acid | US10131648, Compound 66 | US10195178, Compound 66 | US9790198, Compound 66
Type:
Small organic molecule
Emp. Form.:
C31H30O5S
Mol. Mass.:
514.632
SMILES:
COCCOc1cccc(C)c1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12 |r,wD:27.28,(-11.46,3.96,;-10.38,2.87,;-8.89,3.27,;-7.8,2.18,;-6.31,2.58,;-5.22,1.49,;-5.62,0,;-4.53,-1.09,;-3.04,-.69,;-2.65,.8,;-1.16,1.2,;-3.74,1.89,;-3.34,3.37,;-4.24,4.62,;-3.34,5.87,;-1.87,5.39,;-.54,6.16,;.8,5.39,;.8,3.85,;2.13,3.08,;2.13,1.54,;3.46,.77,;3.46,-.77,;4.8,-1.54,;6.13,-.77,;6.13,.77,;4.8,1.54,;7.46,-1.54,;8.8,-.77,;10.13,-1.54,;11.46,-.77,;10.13,-3.08,;7.46,-3.08,;7.46,-4.62,;7.46,-6.16,;-.54,3.08,;-1.87,3.85,)|
Structure:
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