Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300870
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
EC50
19.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US9790198 Publication Date 10/17/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300870
Synonyms:
(3S)-3-[4-([3-[2-(2- Methoxyethoxy)phenyl]-1- benzothiophen-5- yl]methoxy)phenyl] hex-4-ynoic acid | US10131648, Compound 68 | US10195178, Compound 68 | US9790198, Compound 68
Type:
Small organic molecule
Emp. Form.:
C30H28O5S
Mol. Mass.:
500.605
SMILES:
COCCOc1ccccc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12 |r|
Structure:
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