Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300891
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
EC50
20.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US9790198 Publication Date 10/17/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300891
Synonyms:
(3R)-3-(6-((3-(5-(2- Methoxyethoxy)-3- methylpyridin-2- yl)benzo[b]thiophen-5- yl)methoxy)pyridin-3-yl) hex-4-ynoic acid | US10131648, Compound 89 | US10195178, Compound 89 | US9790198, Compound 89
Type:
Small organic molecule
Emp. Form.:
C29H28N2O5S
Mol. Mass.:
516.608
SMILES:
COCCOc1cnc(-c2csc3ccc(COc4ccc(cn4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1 |r|
Structure:
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