Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM347615
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
330±n/a nM
Citation
 Bousba, S; Goldby, A; Jenkins, K; Kinsella, N; Teall, M Piperidine and azepine derivatives as prokineticin receptor modulators US Patent  US9790201 Publication Date 10/17/2017 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM347615
Synonyms:
4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)-1-methyl-1H-pyrazol-3-amine | US9790201, 100 | US9790201, 118 | US9790201, 119
Type:
Small organic molecule
Emp. Form.:
C17H18ClF3N4O
Mol. Mass.:
386.799
SMILES:
Cn1cc(C(=O)N2CCCC(C2)c2ccc(Cl)cc2C(F)(F)F)c(N)n1
Structure:
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