Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM347697
Substrate
n/a
Meas. Tech.
Inhibition Assay
EC50
0.113±n/a nM
Citation
 Aebi, JAmrein, KHornsperger, BKuhn, BLi, DLiu, YMaerki, HPMartin, REMayweg, AVTan, XWang, LWu, J Pyridinyloxy- and phenyloxy-pyrazolyl compounds US Patent  US9790217 Publication Date 10/17/2017 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM347697
Synonyms:
(E)-1-(2-Chlorophenyl)-2-[(6- chloro-3-pyridyl)oxy]-3- (dimethylamino)prop-2-en-1-one | US9790217, 19
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N2O2
Mol. Mass.:
337.201
SMILES:
CN(C)\C=C(\Oc1ccc(Cl)nc1)C(=O)c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: