Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM347708
Substrate
n/a
Meas. Tech.
Inhibition Assay
EC50
1.82±n/a nM
Citation
 Aebi, JAmrein, KHornsperger, BKuhn, BLi, DLiu, YMaerki, HPMartin, REMayweg, AVTan, XWang, LWu, J Pyridinyloxy- and phenyloxy-pyrazolyl compounds US Patent  US9790217 Publication Date 10/17/2017 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM347708
Synonyms:
(E)-1-(3-Chloro-2-fluoro-phenyl)-2- (4-chlorophenoxy)-3-(dimethylamino)prop-2- en-1-one | US9790217, 31
Type:
Small organic molecule
Emp. Form.:
C17H14Cl2FNO2
Mol. Mass.:
354.203
SMILES:
CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1cccc(Cl)c1F
Structure:
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