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TargetTyrosine-protein kinase BTK
LigandBDBM348606
Substrate/Competitorn/a
Meas. Tech.In Vitro BTK Kinase Assay
IC50<100±n/a nM
Citation Bui, MConlon, PCuervo, JHErlanson, DAFan, JGuan, BHopkins, BTJenkins, TJKumaravel, GLugovskoy, AAMarcotte, DPowell, NScott, DSilvian, LTaveras, AWang, DZhong, M Bruton's tyrosine kinase inhibitors US Patent US9790229 Publication Date 10/17/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase BTK
Name:Tyrosine-protein kinase BTK
Synonyms:ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:Enzyme
Mol. Mass.:76289.95
Organism:Homo sapiens (Human)
Description:Q06187
Residue:659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM348606
NameBDBM348606
Synonyms:US9790229, Compound 329
TypeSmall organic molecule
Emp. Form.C21H22ClF5N6O
Mol. Mass.504.884
SMILESNc1ncnc(N2CC[C@@H]([C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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