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Target
Trace amine-associated receptor 1
Ligand
BDBM348641
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
IC50
2.90±n/a nM
Citation
 Cecere, G; Galley, G; Hu, Y; Norcross, R; Pflieger, P; Shen, H 2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives US Patent  US9790230 Publication Date 10/17/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM348641
Synonyms:
1-[3-[(1R,3S,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-3-yl]phenyl]-3-[4-(trifluoromethyl)phenyl]urea | US9790230, Example 3
Type:
Small organic molecule
Emp. Form.:
C19H18F3N3O2
Mol. Mass.:
377.3603
SMILES:
FC(F)(F)c1ccc(NC(=O)Nc2cccc(c2)[C@@H]2O[C@H]3CN[C@@H]2C3)cc1 |r|
Structure:
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