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Target
Trace amine-associated receptor 1
Ligand
BDBM348720
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
IC50
3.50±n/a nM
Citation
 Cecere, G; Galley, G; Hu, Y; Norcross, R; Pflieger, P; Shen, H 2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives US Patent  US9790230 Publication Date 10/17/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_MOUSE | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Protein
Mol. Mass.:
37635.41
Organism:
Mus musculus (Mouse)
Description:
Q923Y8
Residue:
332
Sequence:
MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM348720
Synonyms:
4-Chloro-3-cyclopropyl-N-[4-[(1R,3S,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-3-yl]phenyl]-11H-pyrazole-5-carboxamide | US9790230, Example 82
Type:
Small organic molecule
Emp. Form.:
C18H21ClN4O2
Mol. Mass.:
360.838
SMILES:
N\C(C(=O)Nc1ccc(cc1)[C@@H]1O[C@H]2CN[C@@H]1C2)=C(\Cl)C(=N)C1CC1 |r|
Structure:
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