Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 10
Ligand
BDBM15616
Substrate
EGF receptor peptide
Meas. Tech.
Enzyme Inhibition Assay
Ki
1800±n/a nM
Citation
Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem 50:1280-7 (2007) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
Inhibitor
Name:
BDBM15616
Synonyms:
4-(3-chlorophenyl)-3-[5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]-1H-pyrazole | 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrol-2-yl)(pyrrolidin-1-yl)methanone | Pyrrole Carboxamide Analog 5b
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O
Mol. Mass.:
340.807
SMILES:
Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)N1CCCC1
Substrate
Name:
EGF receptor peptide
Synonyms:
Epidermal Growth Factor Receptor Peptide (EGFRP)
Type:
Peptide
Mol. Mass.:
2318.63
Organism:
n/a
Description:
n/a
Residue:
21
Sequence:
KRELVEPLTPSGEAPNQALLR