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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM283261
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Inhibition Assay LSD-1
IC50
<100±n/a nM
Citation
 Chen, YK; Kanouni, T; Kaldor, SW; Stafford, JA; Veal, JM Inhibitors of lysine specific demethylase-1 US Patent  US10207999 Publication Date 2/19/2019 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM283261
Synonyms:
4-{5-(3-fluoro-4-methoxy-phenyl)- 1-methyl-6-oxo-2-[(3R)- (pyrrolidin-3-ylmethyl)-amino]- 1,6-dihydro-pyrimidin-4-yl}- benzonitrile | US10023543, Example 45 | US10207999, Example 45 | US10328077, Example 45 | US10548896, Example 45 | US10849898, Example 45 | US10960005, Example 45 | US11084793, Example 45 | US9573930, Example 45 | US9771329, Example 45 | US9776974, Example 45
Type:
Small organic molecule
Emp. Form.:
C24H24FN5O2
Mol. Mass.:
433.4781
SMILES:
COc1ccc(cc1F)-c1c(nc(NC[C@@H]2CCNC2)n(C)c1=O)-c1ccc(cc1)C#N |r|
Structure:
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