Target
Lysine-specific histone demethylase 1A
Ligand
BDBM283302
Substrate
n/a
Meas. Tech.
LSD1 CD11b Cellular Assay
IC50
<100±n/a nM
Citation
 Chen, YKKanouni, TKaldor, SWStafford, JAVeal, JM Inhibitors of lysine specific demethylase-1 US Patent  US10207999 Publication Date 2/19/2019 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM283302
Synonyms:
4-[5-(6-dimethylamino-pyridin-3- yl)-1-methyl-2-(4-methylamino- piperidin-1-yl)-6-oxo-1,6-dihydro- pyrimidin-4-yl]-2-fluoro- benzonitrile | US10023543, Example 83 | US10207999, Example 83 | US10328077, Example 83 | US10548896, Example 83 | US10849898, Example 83 | US10960005, Example 83 | US11084793, Example 83 | US9573930, Example 83 | US9771329, Example 83 | US9776974, Example 83
Type:
Small organic molecule
Emp. Form.:
C25H28FN7O
Mol. Mass.:
461.5345
SMILES:
CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(nc2)N(C)C)c(=O)n1C
Structure:
Search PDB for entries with ligand similarity: