Reaction Details Report a problem with these data
Target
G-protein coupled estrogen receptor 1
Ligand
BDBM349618
Substrate
n/a
Meas. Tech.
Estrogen Receptor (ER) Degradation Assay
IC50
<1000±n/a nM
Citation
 Strum, JC Benzothiophene estrogen receptor modulators US Patent  US10208011 Publication Date 2/19/2019 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM349618
Synonyms:
(3-(4-(2-(diethylamino)ethyl)phenoxy)-6- hydroxybenzo[b]thiophen-2-yl)(4-fluoro- 2,6-dimethylphenyl)methanone | US10208011, Compound 112 | US10981887, Compound 112
Type:
Small organic molecule
Emp. Form.:
C29H30FNO3S
Mol. Mass.:
491.617
SMILES:
CCN(CC)CCc1ccc(Oc2c(sc3cc(O)ccc23)C(=O)c2c(C)cc(F)cc2C)cc1
Structure:
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