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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM349633
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
40.0±n/a nM
Citation
 Teall, M 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors US Patent  US10208016 Publication Date 2/19/2019 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM349633
Synonyms:
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidin-4-ylidene)acetonitrile | US10208016, Compound of Example 3 | US10335402, Example 3
Type:
Small organic molecule
Emp. Form.:
C18H19ClN4O2S
Mol. Mass.:
390.887
SMILES:
Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(C#N)c1ccc(Cl)cc1 |(-6.95,-.51,;-6.18,.83,;-7.08,2.07,;-6.18,3.32,;-4.71,2.84,;-3.38,3.61,;-4.71,1.3,;-3.22,.9,;-2.83,2.39,;-3.62,-.58,;-1.74,.51,;-.65,1.59,;.84,1.2,;1.24,-.29,;.15,-1.38,;-1.34,-.98,;2.73,-.69,;3.12,-2.18,;3.52,-3.67,;3.81,.4,;5.3,,;6.39,1.09,;5.99,2.58,;7.08,3.67,;4.51,2.98,;3.42,1.89,)|
Structure:
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