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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM349639
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
150±n/a nM
Citation
 Teall, M 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors US Patent  US10208016 Publication Date 2/19/2019 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM349639
Synonyms:
2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)-2-(4-(trifluoromethoxy)phenypacetonitrile | US10208016, Compound of Example 9 | US10335402, Example 9
Type:
Small organic molecule
Emp. Form.:
C19H19F3N4O3S
Mol. Mass.:
440.439
SMILES:
Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(C#N)c1ccc(OC(F)(F)F)cc1 |(-7.29,-1.99,;-6.52,-.66,;-7.43,.59,;-6.52,1.83,;-5.06,1.36,;-3.72,2.13,;-5.06,-.18,;-3.57,-.58,;-3.17,.9,;-3.97,-2.07,;-2.08,-.98,;-1.68,-2.47,;-.2,-2.87,;.89,-1.78,;.49,-.29,;-.99,.11,;2.38,-2.18,;2.78,-3.67,;3.18,-5.15,;3.47,-1.09,;4.96,-1.49,;6.05,-.4,;5.69,1.13,;6.78,2.22,;6.38,3.7,;5.98,5.19,;7.86,4.1,;4.89,3.31,;4.16,1.49,;3.07,.4,)|
Structure:
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