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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM349644
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
760±n/a nM
Citation
 Teall, M 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors US Patent  US10208016 Publication Date 2/19/2019 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM349644
Synonyms:
4-(4-Chlorobenzylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidine | US10208016, Compound of Example 14 | US10335402, Example 14
Type:
Small organic molecule
Emp. Form.:
C17H20ClN3O2S
Mol. Mass.:
365.878
SMILES:
Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=Cc1ccc(Cl)cc1 |(-6.95,-1.65,;-6.18,-.32,;-7.08,.93,;-6.18,2.18,;-4.71,1.7,;-3.38,2.47,;-4.71,.16,;-3.22,-.24,;-2.83,1.25,;-3.62,-1.73,;-1.74,-.64,;-1.34,-2.12,;.15,-2.52,;1.24,-1.43,;.84,.05,;-.65,.45,;2.73,-1.83,;3.81,-.74,;5.3,-1.14,;6.39,-.05,;5.99,1.43,;7.08,2.52,;4.51,1.83,;3.42,.74,)|
Structure:
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