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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM349765
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone H6-Assay 1
EC50
0.300±n/a nM
Citation
 Aspnes, GE; Bagley, SW; Curto, JM; Dowling, MS; Edmonds, D; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Ingle, G; Jiao, W; Limberakis, C; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent  US10208019 Publication Date 2/19/2019 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM349765
Synonyms:
2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperazin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid | US10208019, Example 10A-35
Type:
Small organic molecule
Emp. Form.:
C32H31FN8O3
Mol. Mass.:
594.6387
SMILES:
CCn1cncc1Cn1c(CN2CCN(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O
Structure:
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