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TargetAcidic mammalian chitinase (AMCase)
LigandBDBM349973
Substrate/Competitorn/a
Meas. Tech.Human AMCase Activity Assay
IC50<100±n/a nM
Citation Mazur, MKoralewski, RBorek, BOlejniczak, SCzestkowski, WJPiotrowicz, MCOlczak, JPGolebiowski, AABartoszewicz, AMaziarz, EKowalski, M Substituted amino triazoles useful as human chitinase inhibitors US Patent US10208020 Publication Date 2/19/2019  Article
More Info.:Get all data from this article,  Assay Method
 
Acidic mammalian chitinase (AMCase)
Name:Acidic mammalian chitinase (AMCase)
Synonyms:AMCase | Lung-specific protein TSA1902
Type:Protein
Mol. Mass.:52266.66
Organism:Homo sapiens (Human)
Description:Q9BZP6
Residue:476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM349973
NameBDBM349973
Synonyms:(S)-5-(4-(3-(4-chlorobenzyl)-2,3-dihydropyrido[4,3-f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine | US10208020, Example 63 | US9944624, Ex. 63
TypeSmall organic molecule
Emp. Form.C22H26ClN7O
Mol. Mass.439.941
SMILESNc1nnc([nH]1)N1CCC(CC1)N1Cc2ccncc2OC[C@@H]1Cc1ccc(Cl)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a