Reaction Details
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MAP kinase-interacting serine/threonine-protein kinase 1 [1-424]
Ligand
BDBM227732
Substrate
n/a
Meas. Tech.
MKNK1 Kinase High ATP Assay
pH
7.5±n/a
IC50
27±n/a nM
Comments
extracted
Citation
Klar, U; Wortmann, L; Kettschau, G; Pühler, F; Lienau, P; Sülzle, D Substituted pyrazolopyrimidinylamino-indazoles US Patent US9556181 Publication Date 1/31/2017 More Info.:
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1 [1-424]
Synonyms:
MAP kinase signal-integrating kinase 1 (MKNK1) | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47005.82
Organism:
Homo sapiens (Human)
Description:
aa 1-424
Residue:
424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEP
Inhibitor
Name:
BDBM227732
Synonyms:
3-bromo-n-(6-isopropoxy-1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | US9556181, 17 | US9556181, 18 | US9556181, 20 | US9556181, 21
Type:
Small organic molecule
Emp. Form.:
C15H14BrN7O
Mol. Mass.:
388.222
SMILES:
CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12
Structure:
