Reaction Details Report a problem with these data
Target
Fascin
Ligand
BDBM350106
Substrate
n/a
Meas. Tech.
Chemical Library Screens and Analysis
IC50
2000±n/a nM
Citation
 Huang, X; Shue, CY Methods for inhibiting fascin US Patent  US10208043 Publication Date 2/19/2019 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM350106
Synonyms:
N-phenyl-2,3-diphenyl- 1,2,4-thiadiazolium-5- amine | US10208043, # 7 | US10941146, # 7
Type:
Small organic molecule
Emp. Form.:
C20H16N3S
Mol. Mass.:
330.426
SMILES:
N(C1=NC(c2ccccc2)=[N](S1)c1ccccc1)c1ccccc1 |c:10,t:1|
Structure:
Search PDB for entries with ligand similarity: