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Target
Fascin
Ligand
BDBM350122
Substrate
n/a
Meas. Tech.
Chemical Library Screens and Analysis
IC50
4300±n/a nM
Citation
 Huang, X; Shue, CY Methods for inhibiting fascin US Patent  US10208043 Publication Date 2/19/2019 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM350122
Synonyms:
N-(4-fluorobenzyl)-2-(4- oxo-1-(S,S-dioxo- tetrahydrothiophen-3-yl)- 1H-pyrazolo[3,4- d]pyrimidin-5(4H)- yl)acetamide | US10208043, # 24 | US10941146, # 24
Type:
Small organic molecule
Emp. Form.:
C18H18FN5O4S
Mol. Mass.:
419.43
SMILES:
Fc1ccc(CNC(=O)Cn2cnc3n(ncc3c2=O)C2CCS(=O)(=O)C2)cc1
Structure:
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