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Target
Cyclin-C/Cyclin-dependent kinase 19
Ligand
BDBM350254
Substrate
n/a
Meas. Tech.
CDK19/Cyclin C Binding Assay
IC50
6.10±n/a nM
Citation
 Pastor Fernández, J; Martínez González, S; Blanco-Aparicio, C; Hernández Higueras, AI; Gómez De La Oliva, CA; Rivero Buceta, V; Riesco Fagundo, RC Condensed tricyclic compounds as protein kinase inhibitors US Patent  US10208056 Publication Date 2/19/2019 
Target
Name:
Cyclin-C/Cyclin-dependent kinase 19
Synonyms:
CDK19/Cyclin C
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 19
Synonyms:
CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028
Type:
Serine/Threonine protein kinase
Mol. Mass.:
56816.68
Organism:
Homo sapiens (Human)
Description:
Q9BWU1
Residue:
502
Sequence:
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
  
Component 2
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM350254
Synonyms:
US10208056, Compound 81
Type:
Small organic molecule
Emp. Form.:
C16H17N3O3
Mol. Mass.:
299.3245
SMILES:
Cn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: