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Target
Egl nine homolog 1
Ligand
BDBM350279
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
14.2±n/a nM
Citation
 Cai, J; Crespo, A; Debenham, J; Du, X; Liu, P; Liu, R; Madsen-Duggan, CB; Quan, W; Sinz, C; Wang, L Inhibitors of HIF prolyl hydroxylase US Patent  US10208060 Publication Date 2/19/2019 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM350279
Synonyms:
2-(4-hydroxy-1-(5- methoxypyridin-2-yl)-2-oxo- 1,2,5,7-tetrahydrofuro[3,4-b] pyridine-3-carboxamido) acetic acid | US10208060, Example 10
Type:
Small organic molecule
Emp. Form.:
C16H15N3O7
Mol. Mass.:
361.3062
SMILES:
COc1ccc(nc1)-n1c2COCc2c(O)c(C(=O)NCC(O)=O)c1=O
Structure:
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